no if you select a new instrument from the file menu then the macro selections are empty except for the first micro Vibrato. This isn't the same thing as dragging the crosshair to an empty box. That's modulating with what's already assigned to the macro.
If you want to load something into the macros (in the lower right hand corner of the window) you can't assign anything into these such as reverb, delay, fx or anything. If you load an instrument in they are programed into the patch.
You can take those and save those as a template by resetting everything else but that's the only way to do it. The user guide states that you can right click to do that in the standalone version but to consult the daw to do that as a plugin.